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Mitochondria released from injured cells activate endothelial cells (ECs), fostering inflammatory processes, including allograft rejection. The stimulator of interferon genes (STING) senses endogenous mitochondrial DNA, triggering innate immune activation via NF‐κB signaling. Here, we show that exogenous mitochondria exposure induces EC STING‐NF‐κB activation, promoting EC/effector memory T cell adhesion,...