Search results for: C. Smith

Items from 1 to 20 out of 4,212 results

article

Advances, recognition, and interpretation of molecular heterogeneity among conventional and subtype histology of urothelial carcinoma (UC): a survey among urologic pathologists and comprehensive review of the literature

Anandi Lobo, Katrina Collins, Seema Kaushal, Andres M Acosta, more

Aims Urothelial carcinoma (UC) demonstrates significant molecular and histologic heterogeneity. The WHO 2022 classification has hinted at adding molecular signatures to the morphologic diagnosis. As morphology and associated molecular repertoire may potentially translate to choices of and response to therapy and relapse rate, broader acceptability of recognizing these key features among uropathologists...

article

Genetic rescue often leads to higher fitness as a result of increased heterozygosity across animal taxa

Julia G. Clarke, Adam C. Smith, Catherine I. Cullingham

Molecular Ecology > 33 > 19 > n/a - n/a

Biodiversity loss has reached critical levels partly due to anthropogenic habitat loss and degradation. These landscape changes are damaging as they can fragment species distributions into small, isolated populations, resulting in limited gene flow, population declines and reduced adaptive potential. Genetic rescue, the translocation of individuals to increase genetic diversity and ultimately fitness,...

article

Diagnosis of systemic mastocytosis with cryptic deletion of TET2 and DNMT3A resulting from unbalanced translocation

Signy Chow, Stephanie Lee, August Lin, Kenneth J. Craddock, more

British Journal of Haematology > 205 > 3 > 961 - 966

Systemic mastocytosis (SM) is a rare haematological neoplasm associated with the gain of function mutation KIT D816V in 90% of adult patients. Classically, cytogenetic aberrations are not common except in cases of SM associated with another haematological neoplasm. We highlight here an unusual clinical presentation of SM and demonstrate the utility of advanced cytogenetic analysis (optical genome...

article

How well do parents identify their child's baby teeth? Engagement and accuracy of parent‐reported information on a tooth checklist survey

Mona Le Luyer, Molly E. Boll, Simone A. M. Lemmers, Samantha J. Stoll, more

Community Dentistry and Oral Epidemiology > 52 > 5 > 731 - 738

Objectives Naturally exfoliated primary teeth are being increasingly collected in child development studies. Most of these odontological collections and tooth biobanks use parent‐reported information from questionnaires or tooth checklists to collect data on offspring teeth. To the best of the authors' knowledge, no studies have assessed parental engagement in tooth checklists, nor parental accuracy...

article

Prognostic clinical decision support for pneumonia in the emergency department: A randomized trial

Derek J. Williams, Hui Nian, Srinivasan Suresh, Jason Slagle, more

Journal of Hospital Medicine > 19 > 9 > 802 - 811

Background Hospitalization rates for childhood pneumonia vary widely. Risk‐based clinical decision support (CDS) interventions may reduce unwarranted variation. Methods We conducted a pragmatic randomized trial in two US pediatric emergency departments (EDs) comparing electronic health record (EHR)‐integrated prognostic CDS versus usual care for promoting appropriate ED disposition in children...

article

Behavioural phenotype of SYNGAP1‐related intellectual disability

M. P. Kranak, G. Rooker, C. Smith‐Hicks

Journal of Intellectual Disability Research > 68 > 9 > 1036 - 1049

Background SYNGAP1‐ related intellectual disability (SYNGAP1‐ID) is a rare genetic disorder presenting with intellectual disability (ID), epilepsy, maladaptive behaviours and communication challenges. To date, few studies have assessed the context in which these maladaptive behaviours occur. This study aims to investigate the prevalence of problem behaviours, characterise the behavioural phenotype...

article

Improving self‐management behaviour through a digital lifestyle intervention: An internal pilot study

Courtney J. Lightfoot, Thomas J. Wilkinson, Noemi Vadaszy, Matthew P. M. Graham‐Brown, more

Journal of Renal Care > 50 > 3 > 283 - 296

Background Self‐management is a key component of successful chronic kidney disease (CKD) management. Here, we present the findings from the internal pilot of a multicentre randomised controlled trial (RCT) aimed to test the effect of a digital self‐management programme (‘My Kidneys & Me’ (MK&M)). Methods Participants (aged ≥18 years and CKD stages 3‐4) were recruited from hospital kidney...

article

Association between multimorbidity and postoperative mortality in patients undergoing major surgery: a prospective study in 29 countries across Europe

STARSurg Collaborative, EuroSurg Collaborative, S. K. Kamarajah, O. Kouli, more

Anaesthesia > 79 > 9 > 945 - 956

Background Multimorbidity poses a global challenge to healthcare delivery. This study aimed to describe the prevalence of multimorbidity, common disease combinations and outcomes in a contemporary cohort of patients undergoing major abdominal surgery. Methods This was a pre‐planned analysis of a prospective, multicentre, international study investigating cardiovascular complications after major...

article

Sudden Shift to Telehealth in COVID‐19: A Retrospective Cohort Study of Disparities in Use of Telehealth for Prenatal Care in a Large Midwifery Service

Denise C. Smith, E. Brie Thumm, Jessica Anderson, Katherine Kissler, more

Journal of Midwifery & Women's Health > 69 > 4 > 522 - 530

Introduction The coronavirus disease 2019 (COVID‐19) pandemic created disruption in health care delivery, including a sudden transition to telehealth use in mid‐March 2020. The purpose of this study was to examine changes in the mode of prenatal care visits and predictors of telehealth use (provider‐patient messaging, telephone visits, and video visits) during the COVID‐19 pandemic among those receiving...

article

Comparative Effectiveness of a Second Tumor Necrosis Factor Inhibitor Versus a Non–Tumor Necrosis Factor Biologic in the Treatment of Patients With Polyarticular‐Course Juvenile Idiopathic Arthritis

Melissa L. Mannion, Shahla Amin, Stephen Balevic, Min‐Lee Chang, more

Arthritis Care & Research > 76 > 8 > 1090 - 1098

Objective The objective of this study was to compare the effectiveness of a second tumor necrosis factor inhibitor (TNFi) versus a non‐TNFi biologic following discontinuation of a TNFi for patients with polyarticular‐course juvenile idiopathic arthritis (pJIA). Methods Using the Childhood Arthritis and Rheumatology Research Alliance Registry, patients with pJIA who started receiving a second biologic...

article

Eating disorder symptoms and comorbid mental health risk among teens recruited to a digital intervention research study via two online approaches

Erin Kasson, Hannah S. Szlyk, Xiao Li, Anna Constantino‐Pettit, more

International Journal of Eating Disorders > 57 > 7 > 1518 - 1531

Introduction It is crucial to identify and evaluate feasible, proactive ways to reach teens with eating disorders (EDs) who may not otherwise have access to screening or treatment. This study aimed to explore the feasibility of recruiting teens with EDs to a digital intervention study via social media and a publicly available online ED screen, and to compare the characteristics of teens recruited...

article

Fill‐spill‐merge terrain analysis reveals topographical controls on Canadian river runoff

Nimisha Wagle, Laurence C. Smith

Hydrological Processes > 38 > 7 > n/a - n/a

Digital Elevation Models (DEMs) are a crucial tool for watershed analysis, offering valuable insights into landscape‐scale hydrology. Traditional watershed delineations are derived by filling a DEM to force flow paths through topographic depressions, thus creating a continuous drainage network throughout the domain. However, this approach is challenged in landscapes with abundant real‐world depression...

article

Anaplastic sarcoma of the kidney (DICER1‐sarcoma of the kidney): A report from the International Pleuropulmonary Blastoma/DICER1 Registry

Peter J. Schoettler, Caroline C. Smith, Miki Nishitani, Anne K. Harris, more

Pediatric Blood & Cancer > 71 > 8 > n/a - n/a

Background Anaplastic sarcoma of the kidney (ASK) is a DICER1‐related neoplasm first identified as a distinctive tumor type through the evaluation of unusual cases of putative anaplastic Wilms tumors. Subsequent case reports identified the presence of biallelic DICER1 variants as well as progression from cystic nephroma, a benign DICER1‐related neoplasm. Despite increasing recognition of ASK as a...

article

Impact of postoperative cardiovascular complications on 30‐day mortality after major abdominal surgery: an international prospective cohort study

STARSurg Collaborative, the EuroSurg Collaborative, O Kouli, D Chaudhry, more

Anaesthesia > 79 > 7 > 715 - 724

Cardiovascular complications after major surgery are associated with increases in morbidity and mortality. There is confusion over definitions of cardiac injury or complications, and variability in the assessment and management of patients. This international prospective cohort study aimed to define the incidence and timing of these complications and to investigate their impact on 30‐day all‐cause...

article

The equine umbilical cord in clinically healthy pregnancies

Jessica M. Lawson, Kristien Verheyen, Ken C. Smith, Jill S. Bryan, more

Equine Veterinary Journal > 56 > 4 > 742 - 750

Background Excessive umbilical cord length (UCL) is associated with equine pregnancy loss. However, a lack of UCL reference values makes it difficult to define excessive UCL. Further, factors associated with differences in UCL are poorly understood. Objectives To (i) report the total, allantoic and amniotic UCL in healthy term pregnancies in Thoroughbreds, (ii) describe the relationship between...

article

Response to Correspondence to “Short‐course subcutaneous treatment with PQ Grass strongly improves symptom and medication scores in grass allergy”

P. J. Kam, S. Zielen, J. A. Bernstein, U. Berger, more

Allergy > 79 > 6 > 1637 - 1638

article

FOXO1 regulates wound‐healing responses in human gingival fibroblasts

Leticia Rojas, Nicolás Tobar, Javier Espinoza, Susana Ríos, more

Journal of Periodontal Research > 59 > 3 > 611 - 621

Background and objective Forkhead box‐O 1 (FOXO1) is a transcription factor actively involved in oral wound healing at the epithelial barrier. However, less is known regarding the role of FOXO1 during the tissue repair response in the connective tissue compartment. This study explored the involvement of FOXO1 in the modulation of fibroblast activity related to wound healing. Methods Primary cultures...

article

Timing matters in (mis)identifying moderators and mediators of digital interventions for eating disorders: Commentary on McClure et al. (2023)

Jessica L. Schleider, Arielle C. Smith, Andrea K. Graham

International Journal of Eating Disorders > 57 > 5 > 1141 - 1144

This commentary addresses the challenges in identifying consistent moderators and mediators of psychological treatments for eating disorders (EDs), as highlighted by McClure et al. (International Journal of Eating Disorders, 2023) in their systematic review. Specifically, we discuss the often‐overlooked importance of temporal context (when an intervention is delivered), alongside sociodemographic...

article

Caregiver skills training for caregivers of individuals with neurodevelopmental disorders: A systematic review and meta‐analysis

Brian Reichow, Cary Kogan, Corrado Barbui, Daniel Maggin, more

Developmental Medicine & Child Neurology > 66 > 6 > 713 - 724

Aim To systematically review the effectiveness of caregiver and parent skills training programs, including caregiver‐mediated interventions, for caregivers of individuals with neurodevelopmental disorders. Method We conducted a systematic review with a random‐effects meta‐analysis. We searched 11 electronic databases through July 2021 and used a snowball methodology to locate relevant articles...

article

Capturing the Range of Disease Involvement in Localized Scleroderma: The Localized Scleroderma Total Severity Scale

Suzanne C. Li, C. Egla Rabinovich, Mara L. Becker, Kathryn S. Torok, more

Arthritis Care & Research > 76 > 5 > 616 - 626

Objective Juvenile localized scleroderma (jLS) is a chronic autoimmune disease commonly associated with poor outcomes, including contractures, hemiatrophy, uveitis, and seizures. Despite improvements in treatment, >25% of patients with jLS have functional impairment. To improve patient evaluation, our workgroup developed the Localized scleroderma Total Severity Scale (LoTSS), an overall disease...

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INFONA - science communication portal

Search results for: C. Smith

Advances, recognition, and interpretation of molecular heterogeneity among conventional and subtype histology of urothelial carcinoma (UC): a survey among urologic pathologists and comprehensive review of the literature

Genetic rescue often leads to higher fitness as a result of increased heterozygosity across animal taxa

Diagnosis of systemic mastocytosis with cryptic deletion of TET2 and DNMT3A resulting from unbalanced translocation

How well do parents identify their child's baby teeth? Engagement and accuracy of parent‐reported information on a tooth checklist survey

Prognostic clinical decision support for pneumonia in the emergency department: A randomized trial

Behavioural phenotype of SYNGAP1‐related intellectual disability

Improving self‐management behaviour through a digital lifestyle intervention: An internal pilot study

Association between multimorbidity and postoperative mortality in patients undergoing major surgery: a prospective study in 29 countries across Europe

Sudden Shift to Telehealth in COVID‐19: A Retrospective Cohort Study of Disparities in Use of Telehealth for Prenatal Care in a Large Midwifery Service

Comparative Effectiveness of a Second Tumor Necrosis Factor Inhibitor Versus a Non–Tumor Necrosis Factor Biologic in the Treatment of Patients With Polyarticular‐Course Juvenile Idiopathic Arthritis

Eating disorder symptoms and comorbid mental health risk among teens recruited to a digital intervention research study via two online approaches

Fill‐spill‐merge terrain analysis reveals topographical controls on Canadian river runoff

Anaplastic sarcoma of the kidney (DICER1‐sarcoma of the kidney): A report from the International Pleuropulmonary Blastoma/DICER1 Registry

Impact of postoperative cardiovascular complications on 30‐day mortality after major abdominal surgery: an international prospective cohort study

The equine umbilical cord in clinically healthy pregnancies

Response to Correspondence to “Short‐course subcutaneous treatment with PQ Grass strongly improves symptom and medication scores in grass allergy”

FOXO1 regulates wound‐healing responses in human gingival fibroblasts

Timing matters in (mis)identifying moderators and mediators of digital interventions for eating disorders: Commentary on McClure et al. (2023)

Caregiver skills training for caregivers of individuals with neurodevelopmental disorders: A systematic review and meta‐analysis

Capturing the Range of Disease Involvement in Localized Scleroderma: The Localized Scleroderma Total Severity Scale

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