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The present investigation was carried out to investigate if soluble mediators present in tumour microenvironment and systemic circulation of a tumour-bearing host can regulate growth properties and response of the cells of a T cell lymphoma to chemotherapeutic drug: cisplatin, depending on the stage of tumour progression. In order to investigate this, tumour cells of a murine T cell lymphoma, designated...
The antigen presenting ability of the murine peritoneal macrophages in response to coincubation, in vitro, with Dalton's lymphoma (DL) cells was investigated. The antigen presenting ability of the macrophages was observed to increase on in vitro treatment with lipopolysaccharide (LPS) (10 μg/ml) and cisplatin (5 μg/ml). Coincubation of the macrophages with DL cells or DL-conditioned medium (DLCM)...
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