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Bone quality encompasses bone properties that contribute to fracture risk, such as bone stiffness, microstructure, matrix constituents or tissue material properties. These aspects cannot be quantified in-vivo except for stiffness, a surrogate biomarker of strength, which can be assessed using quantitative ultrasound techniques. To better predict bone fracture risk, investigating the relationships...
X-ray phase computed tomography (CT) offers higher sensitivity than conventional X-ray CT. A new phase-CT instrument producing a nano-focused beam has been developed at the ESRF (European Synchrotron Radiation Facility) for nano-imaging. In order to obtain final images, a suited phase retrieval algorithm is necessary, which is attracting broader interest recently. In this paper, we explicit the 3D...
Imaging of the trabecular bone network has made significant advances in the last decade thanks to the outstanding development of 3D X-ray micro-CT. Compared to standard histomorphometry, this technique provides non-destructively 3D images of the trabecular bone permitting a so-called model-independent quantification of this network. Today, the assessment of the bone Lacuno-Canalicular Network (LCN)...
We present a method for phase microtomography based on X-ray propagation based phase contrast imaging for multi-material objects. Previously, homogeneous composition assumptions have been in the Radon domain to overcome low sensitivity in the low frequency range. Here, we introduce a prior in the object domain based on multiple, but known, materials in the sample. This is achieved by first reconstructing...
With hard X-rays synchrotron beams, phase contrast can be obtained with the measurement of the Fresnel diffraction intensity patterns associated to a phase shift induced by the object. We have studied the resolution of this inverse problem with an iterative thresholding algorithm in wavelet coordinates combined with an iterative nonlinear method with a Tikhonov regularization. The phase retrieval...
With hard X-rays synchrotron beams, phase contrast can be obtained with the measurement of the Fresnel diffraction intensity patterns associated to a phase shift induced by the object. We have studied the resolution of this inverse problem with an iterative thresholding algorithm in wavelet coordinates combined with an iterative nonlinear method with a Tikhonov regularization and projection operators...
Biological microscopic imaging is receiving increasing interest with the development of new modalities. In this context Synchrotron Radiation (SR) Nano-CT demonstrates a high potential in opening new horizons. We recall the principle of SR micro-CT and its advantages over standard X-ray micro-CT in terms of accuracy and signal to noise ratio. We briefly present data acquisition and reconstruction...
In zoom-in tomography, the aim is to image a region of interest lying partially or fully within the imaged object, using a high resolution tomographic scan covering only the ROI, and a low resolution scan covering the whole object. We analyze the problem from a multiresolution point of view and propose an algorithm for combining the two data sets using the discrete wavelet transform and the Haar wavelet...
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