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Tough and rubber-like physically crosslinked hydrogels were prepared by blending of concentrated aqueous solutions of poly(vinyl alcohol) (PVA) and poly(sodium L-glutamate) (PSLG) in an autoclave under 2 atm pressure at 120°C. There are three types of water in every blend hydrogel, i.e. free water, unfrozen water (namely bound water), and frozen bound water. Unfrozen water content increases with...
It is not uncommon for peptides and structurally-similar non-peptides to have poor intestinal permeability and low oral bioavailability. One possible way to solve a permeability problem is to formulate the compound with membrane permeation-enhancing excipients. Important criteria for success of this approach are: (1) achieving reproducible intestinal permeation, (2) doing so without causing toxicity,...
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