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Under eons of evolutionary and environmental pressure, biological systems have developed strong and lightweight peptide‐based polymeric materials by using the 20 naturally occurring amino acids as principal monomeric units. These materials outperform their man‐made counterparts in the following ways: 1) multifunctionality/tunability, 2) adaptability/stimuli‐responsiveness, 3) synthesis and processing...
This article describes results on using steered molecular dynamics (SMD) simulations and experimental single-molecule force spectroscopy (SMFS) to investigate the relationship between hydrogen bonding and mechanical stability of a series of homodimeric β-sheet mimics. The dimers consisting of 4, 6, and 8 H-bonding sites were modeled in explicit chloroform solvent and the rupture force was studied...
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