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Altered cytokine profiles and imbalanced frequencies of CD4 + T helper cell subsets are thought to be linked with HIV-1/AIDS pathogenesis, but the causes need to be further clarified. Histamine, a biogenic amine with many functions, shows enhancement in HIV-1 infected individuals, which are considered to link with disease progression, but is poorly understood. This study investigated histamine-assisted...
The lambda interferons (IL-28a, 28b, and IL-29) inhibit the replication of many viruses, but their role in the inhibition of HIV-1 infection remains unclear. During this study, we monitored IL-29 production in HIV-1 infected individuals and analyzed the in vitro and in vivo inhibition of HIV-1 production. Prior treatment with IL-28a or IL-29 induced an antiviral state in cultured primary T-cells,...
Different sliding window sizes and inappropriate subtype references are often selected for identifying HIV-1 recombination, which results in discordant recombination maps even for the same HIV-1 recombinant and affects the tracking of the epidemic of HIV-1 recombinants. Here, we re-analyzed 11 previously characterized HIV-1 CRFs using SimPlot software (version 3.5) with several sliding window sizes...
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