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In our previous work we have shown that the novel synthetic chromone derivative could effectively inhibit the Leishmania donovani replication in vitro and in vivo with less cytotoxicity on murine splenocytes. The aim of the present study is to explore the possible mechanism of anti-leishmanial effect of C-(6-methyl-4-oxo-4H-1-benzopyran-3-yl)-N-(p-tolyl) nitrone (designated as NP1) in vitro and in...
CD40, an antigen-presenting cell expressed costimulatory receptor molecule, binds to T cell expressed CD40-ligand (CD40-L). Using a mouse tumor model, we showed previously that lower CD40/CD40-L expression levels promoted tumor growth whereas higher CD40/CD40-L expression levels led to tumor regression indicating duality in CD40 functions. Whether CD40/CD40-L expressions are regulated in cancer patients...
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