Search results for: K. Ramanathan

Items from 1 to 20 out of 213 results

article

Ensemble modelling of Pirarucu (Arapaima gigas) distribution in biodiversity hotspot to understand its invasion risk

Mohamed Nisin K.M.N., Sreenath K. Ramanathan, Miriam Paul Sreeram, Deepa Sudheesan

Ecology of Freshwater Fish > 32 > 3 > 528 - 537

Invasive species pose a severe threat to biodiversity around the world. Managing the consequences of invasion is difficult in aquatic settings, as the rate at which invaders establish typically outpaces the resources available to eradicate them. For proactive management measures to be implemented, prior knowledge of the probability of invasion is required. In this study, we created a spatial model...

article

Dexmedetomidine for adult cardiac surgery: a systematic review, meta‐analysis and trial sequential analysis

W. H. Poon, R. R. Ling, I. X. Yang, H. Luo, more

Anaesthesia > 78 > 3 > 371 - 380

The effects of dexmedetomidine in adults undergoing cardiac surgery are inconsistent. We conducted a systematic review and meta‐analysis to analyse the effects of peri‐operative dexmedetomidine in adults undergoing cardiac surgery. We searched MEDLINE via Pubmed, EMBASE, Scopus and Cochrane for relevant randomised controlled trials between 1 January 1990 and 1 March 2022. We used the Joanna Briggs...

article

Phase I study of imalumab (BAX69), a fully human recombinant antioxidized macrophage migration inhibitory factor antibody in advanced solid tumours

Devalingam Mahalingam, Manish R. Patel, Jasgit C. Sachdev, Lowell L. Hart, more

British Journal of Clinical Pharmacology > 86 > 9 > 1836 - 1848

Aim Preclinical evidence suggests that oxidized macrophage migration inhibitory factor (oxMIF) may be involved in carcinogenesis. This phase 1 study (NCT01765790) assessed the safety, tolerability, pharmacokinetics and antitumour activity of imalumab, an oxMIF inhibitor, in patients with advanced cancer using ‘3 + 3’ dose escalation. Methods In Schedule 1, patients with solid tumours received doses...

article

Multi-Dimensional Screening Strategy for Drug Repurposing with Statistical Framework—A New Road to Influenza Drug discovery

K. Rohini, K. Ramanathan, V. Shanthi

Cell Biochemistry and Biophysics > 2019 > 77 > 4 > 319-333

Influenza virus is known for its intermittent outbreaks affecting billions of people worldwide. Several neuraminidase inhibitors have been used in practice to overcome this situation. However, advent of new resistant mutants has limited its clinical utilization. In the recent years drug repurposing technique has attained the limelight as it is cost effective and reduces the time consumed for drug...

article

Exploring the Lead Compounds for Zika Virus NS2B-NS3 Protein: an e-Pharmacophore-Based Approach

K. Rohini, Pratika Agarwal, B. Preethi, V. Shanthi, more

Applied Biochemistry and Biotechnology > 2019 > 187 > 1 > 194-210

The rapid spread of the Zika virus and its association with the abnormal brain development constitute a global health emergency. With a continuing spread of the mosquito vector, the exposure is expected to accelerate in the coming years. Despite number of efforts, there is still no proper vaccine or medicine to combat this virus. Of note, the NS2B-NS3 protein is proven to be the potential target for...

article

Ligand-Based Pharmacophore Screening Strategy: a Pragmatic Approach for Targeting HER Proteins

Nivya James, K. Ramanathan

Applied Biochemistry and Biotechnology > 2018 > 186 > 1 > 85-108

Targeting ErbB family of receptors is an important therapeutic option, because of its essential role in the broad spectrum of human cancers, including non-small cell lung cancer (NSCLC). Therefore, in the present work, considerable effort has been made to develop an inhibitor against HER family proteins, by combining the use of pharmacophore modelling, docking scoring functions, and ADME property...

article

Second‐line treatment in patients with pancreatic ductal adenocarcinoma: A meta‐analysis

Mohamad Bassam Sonbol, Belal Firwana, Zhen Wang, Diana Almader‐Douglas, more

Cancer > 123 > 23 > 4680 - 4686

BACKGROUND There are limited therapeutic options for treatment‐refractory pancreatic ductal adenocarcinoma (PDAC), with a paucity of data to support the best option after progression on gemcitabine‐based regimens. The authors performed a meta‐analysis to determine the effectiveness of adding oxaliplatin (OX) or various irinotecan formulations to a fluoropyrimidine (FP) after first‐line treatment...

article

Drug Design for ALK-Positive NSCLC: an Integrated Pharmacophore-Based 3D QSAR and Virtual Screening Strategy

Nivya James, V. Shanthi, K. Ramanathan

Applied Biochemistry and Biotechnology > 2018 > 185 > 1 > 289-315

The increasing death rates related to anaplastic lymphoma kinase (ALK)-positive lung cancer culminated in a significant interest in the discovery of novel inhibitors for ALK. In the present research work, pharmacophore-based 3D QSAR modeling and virtual screening strategy have been carried out to address these issues. Initially, a five-point pharmacophore model was developed using the biological data...

article

DOES ST DEPRESSION HELP PREDICT CORONARY ARTERY DISEASE AFTER AN OUT-OF-HOSPITAL CARDIAC ARREST?

C. Cheung, D. Wan, B. Grunau, C. Taylor, more

Canadian Journal of Cardiology > 2017 > 33 > 10(S) > S133

article

REAL-WORLD SAFETY AND EFFICACY OF A ‘PILL-IN-THE-POCKET' APPROACH FOR THE MANAGEMENT OF PAROXYSMAL ATRIAL FIBRILLATION

R. Yao, J. MacGillivray, L. Macle, M. Bennett, more

Canadian Journal of Cardiology > 2017 > 33 > 10(S) > S190

article

THE ROLE OF RACE IN EMERGENCY DEPARTMENT NURSES’ INITIAL CARE OF PATIENTS WITH SUSPECTED ACUTE CORONARY SYNDROME

M.H. Mackay, P.A. Ratner, F.X. Scheuermeyer, G. Veenstra, more

Canadian Journal of Cardiology > 2017 > 33 > 10(S) > S215

article

IS RACISM A FACTOR IN EMERGENCY DEPARTMENT CARE OF PATIENTS WITH SUSPECTED ACUTE CORONARY SYNDROME?

M. Mackay, P. Ratner, G. Veenstra, F. Scheuermeyer, more

Canadian Journal of Cardiology > 2017 > 33 > 10(S) > S125-S126

article

Effects of Aspect Ratio and Loading on the Mechanical Properties of Prosopis Juliflora Fibre-reinforced Phenol Formaldehyde Composites

A. Sujin Jose, A. Athijayamani, K. Ramanathan, S. Sidhardhan

Fibres & Textiles in Eastern Europe > 2017 > Vol. 25, no. 4 (124) > 59--64

In this paper, an attempt was made to use Prosopis juliflora fibres (PJFs) as a reinforcing agent for phenol formaldehyde (PF) composites. Mechanical properties of the composites were studied for various fibre aspect ratios (FAR) and fibre loadings (FL). A scanning electron microscope (SEM) was used to study the fractured surface of the composites. The peak range of mechanical properties was identified...

article

¹⁸F-FDG PET/CT response in a phase 1/2 trial of nab-paclitaxel plus gemcitabine for advanced pancreatic cancer

Ronald L. Korn, Daniel D. Von Hoff, Mitesh J. Borad, Markus F. Renschler, more

Cancer Imaging > 2017 > 17 > 1 > 1-10

Background Positron emission tomography (PET) is poised to become a useful imaging modality in staging and evaluating therapeutic responses in patients with metastatic pancreatic cancer (mPC). This analysis from a phase 1/2 study examined the utility of early PET imaging in patients with mPC treated with nab-paclitaxel plus gemcitabine. Methods Tumors were measured by [¹⁸F]2-fluoro-2-deoxyglucose...

article

Phase I dose escalation study of NMS-1286937, an orally available Polo-Like Kinase 1 inhibitor, in patients with advanced or metastatic solid tumors

Glen J. Weiss, Gayle Jameson, Daniel D. Hoff, Barbara Valsasina, more

Investigational New Drugs > 2018 > 36 > 1 > 85-95

Summary Background Pharmacological inhibition of polo-like kinase 1 (PLK1) represents a new approach for the treatment of solid tumors. This study was aimed at determining the first cycle dose-limiting toxicities (DLTs) and related maximum tolerated dose (MTD) of NMS-1286937, a selective ATP-competitive PLK1-specific inhibitor. Secondary objectives included evaluation of its safety and pharmacokinetic...

article

Discovery of Therapeutic Lead Molecule Against β-Tubulin Using Computational Approach

K. Ramanathan, Kanika Verma, Naina Gupta, V. Shanthi

Interdisciplinary Sciences: Computational Life Sciences > 2018 > 10 > 4 > 734-747

Virtual screening strategy was performed against the target β-tubulin to overcome paclitaxel resistance in blood cancer types. In essence, A185T and A248V are two such important mutations frequently observed in clinical trials that confer paclitaxel resistance. In the present investigation, compounds from NPACT database were filtered by pharmacokinetics, toxicity and binding energy values. A total...

article

Discovery of Potent ALK Inhibitors Using Pharmacophore-Informatics Strategy

Nivya James, K. Ramanathan

Cell Biochemistry and Biophysics > 2018 > 76 > 1-2 > 111-124

Anaplastic lymphoma kinase is a tyrosine kinase receptor protein belonging to insulin receptor superfamily. Gene fusions in anaplastic lymphoma kinase are associated with non-small cell lung cancer development. Hence, they are of immense importance in targeted therapies. Thus, for the treatment of non-small cell lung cancer, effective anaplastic lymphoma kinase inhibitors are of great significance...

article

Bioactive Amento flavone isolated from Cassia fistula L. leaves exhibits therapeutic efficacy

M. Srividhya, H. Hridya, V. Shanthi, K. Ramanathan

00003 Biotech > 2017 > 7 > 1 > 1-5

Novel natural compounds endowed with sound bioactivities are currently the utmost need as leads toward drug discovery. For the first time, here, we report the presence of Amentoflavone (biflavonoid) in the leaves of Cassia fistula L. Structural characterization was carried out using ultraviolet–visible spectrophotometer, Fourier transform infrared, nuclear magnetic resonance, and thin-layer chromatography...

article

Spectroscopic Identification and Molecular Modeling of Diethyl 7-hydroxytrideca-2, 5, 8, 11-tetraenedioate: a Herbicidal Compound from Streptomyces sp.

P. Priya dharsini, D. Dhanasekaran, P. M. Gopinath, K. Ramanathan, more

Arabian Journal for Science and Engineering > 2017 > 42 > 6 > 2217-2227

The genus Streptomyces is the wealthiest authority of bioactive compounds with their immense array of chemical substances and activities. With this view, about 10 soil Streptomyces isolates that inhibit more than a weed among Echinochola crusigalli L., Amaranthus spinosus L. and Cyperusrotundus L. under moist chamber and roll towel paper assay were selected from a total of 118 isolates. Based on the...

article

COMPARISON OF THERMODILUTION AND INDIRECT FICK CARDIAC OUTPUTS IN PULMONARY ARTERY HYPERTENSION

A. Alkhodair, M. Tsang, K. Ramanathan, J. Swiston, more

Canadian Journal of Cardiology > 2016 > 32 > 10(S1) > S72

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INFONA - science communication portal

Search results for: K. Ramanathan

Ensemble modelling of Pirarucu (Arapaima gigas) distribution in biodiversity hotspot to understand its invasion risk

Dexmedetomidine for adult cardiac surgery: a systematic review, meta‐analysis and trial sequential analysis

Phase I study of imalumab (BAX69), a fully human recombinant antioxidized macrophage migration inhibitory factor antibody in advanced solid tumours

Multi-Dimensional Screening Strategy for Drug Repurposing with Statistical Framework—A New Road to Influenza Drug discovery

Exploring the Lead Compounds for Zika Virus NS2B-NS3 Protein: an e-Pharmacophore-Based Approach

Ligand-Based Pharmacophore Screening Strategy: a Pragmatic Approach for Targeting HER Proteins

Second‐line treatment in patients with pancreatic ductal adenocarcinoma: A meta‐analysis

Drug Design for ALK-Positive NSCLC: an Integrated Pharmacophore-Based 3D QSAR and Virtual Screening Strategy

DOES ST DEPRESSION HELP PREDICT CORONARY ARTERY DISEASE AFTER AN OUT-OF-HOSPITAL CARDIAC ARREST?

REAL-WORLD SAFETY AND EFFICACY OF A ‘PILL-IN-THE-POCKET' APPROACH FOR THE MANAGEMENT OF PAROXYSMAL ATRIAL FIBRILLATION

THE ROLE OF RACE IN EMERGENCY DEPARTMENT NURSES’ INITIAL CARE OF PATIENTS WITH SUSPECTED ACUTE CORONARY SYNDROME

IS RACISM A FACTOR IN EMERGENCY DEPARTMENT CARE OF PATIENTS WITH SUSPECTED ACUTE CORONARY SYNDROME?

Effects of Aspect Ratio and Loading on the Mechanical Properties of Prosopis Juliflora Fibre-reinforced Phenol Formaldehyde Composites

¹⁸F-FDG PET/CT response in a phase 1/2 trial of nab-paclitaxel plus gemcitabine for advanced pancreatic cancer

Phase I dose escalation study of NMS-1286937, an orally available Polo-Like Kinase 1 inhibitor, in patients with advanced or metastatic solid tumors

Discovery of Therapeutic Lead Molecule Against β-Tubulin Using Computational Approach

Discovery of Potent ALK Inhibitors Using Pharmacophore-Informatics Strategy

Bioactive Amento flavone isolated from Cassia fistula L. leaves exhibits therapeutic efficacy

Spectroscopic Identification and Molecular Modeling of Diethyl 7-hydroxytrideca-2, 5, 8, 11-tetraenedioate: a Herbicidal Compound from Streptomyces sp.

COMPARISON OF THERMODILUTION AND INDIRECT FICK CARDIAC OUTPUTS IN PULMONARY ARTERY HYPERTENSION

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