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The disruption of gastric mucosal antioxidant defense system and its relation to the development of gastric mucosal lesions was examined in Donryu rats treated once daily with compound 48/80 (0.75 mg/kg body weight), a mast cell degranulator, over a four day period. Mucosal lesions appeared after the 1st treatment and developed as the treatment was repeated. Mucosal lipid peroxide levels increased...
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