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Prion diseases are neurodegenerative disorders associated with a conformational change of the normal cellular isoform of the prion protein (PrPC) to an abnormal scrapie isoform (PrPSc). human prion protein (hPrPC) is able to bind up to six Cu(II) ions. Four of them are distributed in the octarepeat domain, containing four tandem-repetitions of the sequence PHGGGWGQ. Immediately outside the octarepeat...
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