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Foot-and-mouth disease virus (FMDV) is the most contagious pathogen of cloven-hoofed animals. Previous studies have demonstrated that type I interferons [alpha/beta interferons (IFN-α/βs)] can suppress FMDV replication and spread. Conversely, FMDV can also inhibit IFN-α expression in infected cells by blocking cap-dependent translation. To overcome the blockade on IFN-α mRNA translation during FMDV...
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