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In article number 1603830, by Sijin Liu and co‐workers, the exposure of multi‐wall carbon nanotubes (MWCNTs) alters hepatic hepcidin‐mediated systemic iron homeostasis through pro‐inflammatory responses in mice, leading to limited iron availability for red blood cell formation, and eventually the development of anemia of inflammation. This study opens a new path to understanding the biological impacts...
Although numerous toxicological studies have been performed on carbon nanotubes (CNTs), a few studies have investigated their secondary and indirect effects beyond the primary target tissues/organs. Here, a cascade of events are investigated: the initiating event and the subsequent key events necessary for the development of phenotypes, namely CNT‐induced pro‐inflammatory effects on iron homeostasis...
Among the numerous health conditions environmental pollutants can cause, chronic exposure to pollutants including persistent organic pollutants (POPs) and heavy metals has been shown to disturb a specific biological homeostatic process, the iron metabolism in human body. Disorders of iron metabolism are among the common diseases of humans and encompass a broad spectrum of diseases with different clinical...
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