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Airway inflammation is a key pathological feature of asthma which underlies its clinical presentation.To examine whether adding a leukotriene modifier to an inhaled corticosteroid produces further clinical and/or anti-inflammatory benefits in patients symptomatic on short-acting β 2 -agonists.Patients uncontrolled on short-acting β 2 -agonists were treated for 12 weeks with either...
Little is known about the use of biomarkers in guiding treatment decisions in routine asthma management. The objective of this study was to determine whether adding a LABA to an ICS would control bronchial hyperresponsiveness (BHR) at an overall lower dose of ICS when titration of medication was based upon the assessment of routine clinical measures with or without the measurement of BHR.After a 2-week...
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