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Measurements of extracelluar pH (pH e )in vivohave shown that the microenvironment in tumors is more acidic than in normal tissue. However, both human and animal tumor cells have been shown to have an intracellular pH (pH i ) on the alkaline side of neutrality (pH 7.1–7.2). This gives rise to a reversed pH gradient between tumors and normal tissue which implies that cells within solid...