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Objective
Intracranial (intrahippocampal or intra‐amygdala) administration of kainate in rodents leads to spatially restricted brain injury and development of focal epilepsy with characteristics that resemble mesial temporal lobe epilepsy. Such rodent models are used both in the search for more effective antiseizure drugs (ASDs) and in the development of antiepileptogenic strategies. However, it...
The intrahippocampal kainate mouse model of mesial temporal lobe epilepsy is increasingly being used for studies on epileptogenesis and antiepileptogenesis. Almost all previous studies used male mice for this purpose, and no study is available in this or other models of acquired epilepsy that directly compared epileptogenesis in female and male rodents. Epidemiological studies suggest that gender...
Epilepsy research is undergoing a conceptual shift that is moving away from preventing seizures to preventing epilepsy by treatments that modify the epileptogenic process induced by a variety of brain insults. Evidence from animal experiments suggests that epilepsy prevention or modification is possible, but translating laboratory findings into successful therapies will require more scientific discoveries...
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