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The K‐Ras GTPase is a major target in anticancer drug discovery. However, direct interference with signaling by K‐Ras has not led to clinically useful drugs yet. Correct localization and signaling by farnesylated K‐Ras is regulated by the prenyl binding protein PDEδ. Interfering with binding of PDEδ to K‐Ras by means of small molecules provides a novel opportunity to suppress oncogenic signaling....
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