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The doppel protein (Dpl) is the first homologue of the prion protein (PrPC) to be discovered; it is overexpressed in transgenic mice that lack the prion gene, resulting in neurotoxicity. The whole prion protein is able to inhibit Dpl neurotoxicity, and its N‐terminal domain is the determinant part of the protein function. This region represents the main copper(II) binding site of PrPC. Dpl is able...
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