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Electronic cigarettes (e-cig), which are promoted as safe alternatives to tobacco cigarettes or as aides to smoking cessation, are becoming increasingly popular among adult chronic smokers and adolescents experimenting with tobacco products. Despite the known presence of toxicants and carcinogens in e-cig liquid and vapor, the possible carcinogenic effects of e-cig use in humans are unknown.We have...
Methylated cytosines within CpG dinucleotides (mCpGs) along the DNA‐binding domain of the TP53 tumor suppressor gene (exons ∼5–8) are the single most significant mutational target in human cancers. The human p53 knock‐in (Hupki) mouse model was constructed using gene‐targeting technology to create a mouse strain that harbors human wild‐type TP53 DNA sequences spanning exons 4–9 in both copies of the...
Formation of DNA damage is a crucial event in carcinogenesis. Irreparable DNA lesions have the potential to cause mispairing during DNA replication, thereby giving rise to mutations. Critically important mutations in cancer-related genes, i.e., oncogenes and tumor suppressor genes, are key contributors to carcinogenesis. Theoretically, co-localization(s) of persistent DNA lesions and mutational hotspots...
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