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The T‐lymphoma and metastasis gene 1 (TIAM1) encodes a guanine nucleotide‐exchange factor protein (Tiam1) that is specific for the Rho‐family GTPase Rac1 and is important for cell polarity, migration and adhesion. Tiam1 is a large multi‐domain protein that contains several protein–protein binding domains that are important for regulating cellular function. The PHn‐CC‐Ex domain is critical for plasma‐membrane...
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