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New Findings
What is the central question of this study?
It remains unknown whether ageing modulates prostacyclin‐induced cutaneous vasodilatation in women.
What is the main finding and its importance?
Prostacyclin induced cutaneous vasodilatation, albeit the magnitude of increase at lower concentrations of prostacyclin was greater in older relative to young women. This response was associated with...
Key points
In young adults, cyclooxygenase (COX) contributes to the heat loss responses of cutaneous vasodilatation and sweating, and this may be mediated by prostacyclin‐induced activation of nitric oxide synthase (NOS) and calcium‐activated potassium (KCa) channels.
This prostacyclin‐induced response may be diminished in older relative to young adults because ageing is known to attenuate COX‐dependent...
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