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Increasing evidence supports a role of the CD40 receptor-CD40 ligand (CD40-CD40L) interaction in the pathogenesis of Alzheimer's disease (AD). It has previously been shown that this dyad acts synergistically with the Alzheimer amyloid-β peptide to promote microglial activation. Reactive microglia produce potentially neurotoxic substances such as tumor necrosis factor α and the reactive oxygen species...
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