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Several orthogonally protected racemic trans-3-amino-4-hydroxypyrrolidines have been easily prepared from N-Cbz-3,4-epoxypyrrolidine. Resolution of each racemic compound was accomplished by means of lipase-catalyzed aminolysis, transesterification or hydrolysis reactions. In most cases, the corresponding remaining substrates and the products were obtained with very high enantiomeric excesses.
This chapter contains sections titled:
Introduction
Chemoenzymatic Modification of the Sugar
Resolution and Anomeric Separation
Biotransformations that Modify the Base
Transglycosylation for the Synthesis of Nucleosides
Summary
References
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