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Objective: this study determines the effect of prior hypothermia on the cardiovascular responses to norepinephrine (NE) after rewarming. Methods: the experiment was a 2×2 controlled design with four groups of feline animals. The two variables were the presence or absence of previous cooling, and the use or non-use of NE after rewarming. During the ‘cooling’ phase, animals were either cooled using...
Our purpose was to determine if core hypothermia influences physiological responses to norepinephrine (NE); and if rewarming reverses these effects. Animals were instrumented to measure mean arterial pressure (MAP) and cardiac output (CO). Core temperature was manipulated from 37.5 o C (normothermia), to 30 o C (hypothermia) and the back to 37.5 o C (rewarming) using an external...
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