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To test the hypothesis that γ-interferon (IFN-γ) promotes major histocompatibility complex (MHC) class II expression on bone marrow (BM) cell targets that facilitate T-cell−mediated BM destruction in immune-mediated BM failure.Allogeneic lymph node (LN) cells were infused into MHC- or minor histocompatibility antigen−mismatched hosts to induce BM failure. MHC class II and Fas expression and cell apoptosis...
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