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Focused ultrasound with microbubbles is an emerging technique for blood–brain barrier opening. Here, a comprehensive theoretical model of a bubble-fluid-vessel system has been developed which accounts for the bubble's nonspherical oscillations inside a microvessel, and its resulting acoustic emissions. Numerical simulations of unbound and confined encapsulated bubbles were performed to evaluate the...
The objectives of this research are to determine the temperature distribution due to micro-bubble oscillation in a microscopic brain capillary network under acoustic excavation. The Navier-Stokes equations and the modified Rayleigh-Plesset equations were combined to observe micro-bubble oscillation behavior. The Pennes bio-heat transfer equation (BHTE) was applied to model the heat transfer distribution...
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