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Though D 3 receptor antagonists can enhance cognitive function, their sites of action remain unexplored. This issue was addressed employing a model of social recognition in rats, and the actions of D 3 antagonists were compared to D 1 agonists that likewise possess pro-cognitive properties. Infusion of the highly selective D 3 antagonists, S33084 and SB277,011 (0.04–2...
Rationale 5-HT6 receptor antagonists improve cognitive processes in rodents. However, their site(s) of action remains unexplored and their influence upon social memory has been little investigated. Objectives We examined the influence of 5-HT6 receptor ligands upon social memory in rats by use of systemic or local administration into the frontal cortex (FCX), striatum, or nucleus basalis magnocellularis...
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