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In article number 1907267, Stefan Wuttke, Hanna Engelke, and co‐workers describe how lipid‐coated metal–organic framework (MOF) nanoparticles are taken up by cells via endocytosis. Once inside the cell, the MOF nanoparticles are degraded depending on the extracellular pH. The degradation product leads to pyroptosis—a programmed cell death involving the immune system, in which the cell membrane is...
Ion homeostasis is essential for cellular survival, and elevated concentrations of specific ions are used to start distinct forms of programmed cell death. However, investigating the influence of certain ions on cells in a controlled way has been hampered due to the tight regulation of ion import by cells. Here, it is shown that lipid‐coated iron‐based metal–organic framework nanoparticles are able...
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