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Local delivery of serotonin (5-HT) produces a rapid edematous response in soft tissues via increased fluid extravasation which is prevented by 5-HT 2 antagonists such as ketanserin or mianserin. Here we report the effects of a new class of aminoguanidine 5-HT 2 antagonists, with relative selectivity for 5-HT 2A receptors which are potent inhibitors of 5-HT-induced paw...
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