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Background
Evidence links the lectin pathway of complement activation to diabetic kidney disease. Upon carbohydrate‐recognition by pattern‐recognition molecules, eg, mannan‐binding lectin (MBL), the MBL‐associated serine protease (MASP‐2) is activated and initiates the complement cascade. The MASP2 gene encodes MASP‐2 and the alternative splice product MBL‐associated protein 19 (MAp19). Both MAp19...
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