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Parafibromin, encoded by the gene HRPT2, is a tumor suppressor protein associated with the RNA polymerase II‐associated complex, Paf1 complex. HRPT2 mutations were first identified in patients with the multiple endocrine neoplasia syndrome, hyperparathyroidism‐jaw tumor (HPT‐JT) syndrome, and have also been found in sporadic parathyroid and renal tumors. However, the mechanisms by which parafibromin...
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