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Even being a bacterial purine nucleoside phosphorylase (PNP), which normally shows hexameric folding, the Mycobacterium tuberculosis PNP (MtPNP) resembles the mammalian trimeric structure. The crystal structure of the MtPNP apoenzyme was solved at 1.9Å resolution. The present work describes the first structure of MtPNP in complex with phosphate. In order to develop new insights into the rational drug...
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