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HNF1-α is a transcription factor present in β-cells. Mutations in the HNF1-α gene cause maturity-onset diabetes of the young (MODY), but the exact mechanism is not known. Several studies have highlighted genes down-regulated in β-cells lacking this gene, but it is not clear if these are directly regulated by HNF1-α. To better understand this, we used human and mouse genome data to examine 29 genes...
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