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Positive modulators at the benzodiazepine site of α2- and α3-containing GABA A receptors are believed to be anxiolytic. Through oocyte voltage clamp studies, we have discovered two series of compounds that are positive modulators at α2-/α3-containing GABA A receptors and that show no functional activity at α1-containing GABA A receptors. We report studies to improve this functional...
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