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A significant obstacle for successful chemotherapy with paclitaxel (PTX) is multidrug resistance (MDR) in tumor cells. Micelles and mixed micelles were prepared from Pluronic block copolymer P105 or L101 as PTX delivery systems for overcoming MDR. Both micelle systems were covalently modified with the targeting agent folic acid to recognize and bind a variety of tumor cells via their surface-overexpressed...
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