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Most guidelines suggest combination therapy including nucleoside and nucleotide analogues for the treatment of chronic hepatitis B (CHB) with multidrug resistance (MD‐R). However, long‐term combination treatment can evoke high costs and safety problems. Therefore, we investigated the efficacy of tenofovir disoproxil fumarate (TDF) mono‐rescue therapy for viral suppression in patients with CHB exhibiting...
Background & AimsAnalysing the mutation pattern of multidrug resistance (MDR) is important in the treatment of chronic hepatitis B (CHB). In this study, the evolutionary pattern of MDR mutations was investigated in patients receiving entecavir (ETV) rescue therapy.
MethodsEight CHB patients with lamivudine (LAM)‐ and adefovir (ADV)‐resistant mutations showing suboptimal response to ETV and to...
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