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Nucleotide‐binding domain leucine‐rich repeat‐containing receptors (NLRs) are key proteins in the innate immune system. The 14 members of the NLRP family of NLRs contain an N‐terminal pyrin domain which is central for complex formation and signal transduction. Recently, X‐ray structures of NLRP14 revealed an unexpected rearrangement of the α5/6 stem‐helix of the pyrin domain allowing a novel symmetric...
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