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The cover image is based on the Research Article Identification of a new pyruvate kinase M2 isoform (PKM2) activator for the treatment of non‐small‐cell lung cancer (NSCLC), by Run‐Ze Li et al., DOI: 10.1111/cbdd.13354.
Lung cancer is the number one cancer in terms of both mortality and incidence. Cancer cells differ from normal cells in that they can reprogram their metabolism to support a rapid proliferation rate and alter oxidative phosphorylation processes toward lactic acid fermentation, even under aerobic conditions. Therefore, we aimed to identify new compounds that might act as pyruvate kinase M2 isoform...
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