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LMW‐PTP has been associated with the development of colorectal cancer (CRC) and with the resistance to chemotherapy in cancer cells. To clarify its role in vivo, we studied LMW‐PTP expression in Pirc rats (F344/NTac‐Apc am1137), genetically prone to CRC and resistant to apoptosis. In the morphologically normal mucosa (NM) of Pirc rats, a dramatic over‐expression of LMW‐PTP was found compared to wt...
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