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Objective: To test whether the concentrations of amyloid-β (Aβ)40, Aβ42, apolipoprotein E (apoE) and transthyretin in the CSF of normal individuals, are linked to three factors which modulate the risk of Alzheimer's disease (AD): chronological age, gender, and the presence of the apoE4 allele.Methods and results: Proteins were measured by enzyme-linked immunosorbent assays except for transthyretin,...
This report examines plasma amyloid β proteins Aβ40 and Aβ42 and apolipoprotein E (apoE) levels and their relationships with age in non-demented older adults with (N = 32) or without the apoE-ε4 allele (N = 94). Aβ levels did not differ between the groups whereas the ε4 allele was associated with a significant reduction in plasma apoE. In subjects with the ε4 allele, increasing age was associated...
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