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We have previously reported a changed mitochondrial (mt) gene expression in brain from patients with schizophrenia [Schizophr. Res. 14 (1995) 203]; now, we describe the distribution in the mtDNA from lymphocytes of a heteroplasmic sequence variation that was originally found in the mtDNA from the postmortem brain of a patient with schizophrenia. The variant is m.12027T>C and results in the change...
Catechol-O-methyltransferase (COMT) is an enzyme which metabolises catecholamines (e.g. noradrenaline, adrenaline, and dopamine). An amino acid change (Val-108-Met) of COMT correlates with high and low activities (Grossman et al, 1992) and this variance has been postulated to have some relevance to the aetiology of neuropsychiatric disorders. Moreover, psychosis is frequently observed in patients...
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