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The present study evaluated the neurotoxicity of various gangliosides against dopaminergic neurons in mesencephalic cultures. Among them, GD1a and GD1b but not GD3 and GQ1b were found to be neurotoxic against dopaminergic neurons as determined by TH immunocytochemistry and [ 3 H]DA uptake. When quantified and expressed as a percentage of control values, treatment with 60–200μg/ml GD1a and...
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