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A recurring issue in functional neuroimaging is how to link task‐driven haemodynamic blood oxygen level dependent functional MRI (BOLD‐fMRI) responses to underlying neurochemistry at the synaptic level. Glutamate and γ‐aminobutyric acid (GABA), the major excitatory and inhibitory neurotransmitters respectively, are typically measured with MRS sequences separately from fMRI, in the absence of a task...
Edited MRS sequences are widely used for studying γ‐aminobutyric acid (GABA) in the human brain. Several algorithms are available for modelling these data, deriving metabolite concentration estimates through peak fitting or a linear combination of basis spectra. The present study compares seven such algorithms, using data obtained in a large multisite study. GABA‐edited (GABA+, TE = 68 ms MEGA‐PRESS)...
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