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BACKGROUND AND PURPOSE
Manual segmentation of white matter (WM) bundles requires extensive training and is prohibitively labor‐intensive for large‐scale studies. Automated segmentation methods are necessary in order to eliminate operator dependency and to enable reproducible studies. Significant changes in the WM landscape throughout childhood require flexible methods to capture the variance across...
Our aim was to examine the clinical relevance of white matter hyperintensities (WMH) in HIV. We used an automated approach to quantify WMH volume in HIV seropositive (HIV+; n = 65) and HIV seronegative (HIV−; n = 29) adults over age 60. We compared WMH volumes between HIV+ and HIV− groups in cross-sectional and multiple time-point analyses. We also assessed correlations between WMH volumes and cardiovascular,...
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