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We compared the experimental drug ucb L059 with placebo as an add-on therapy in a single-blind, ascending-dose pilot study in 17 patients with refractory epilepsy. The dose of ucb L059 was increased every 4 weeks by 500 mg in a stepwise fashion from 500 to 2,000 mg/day, and patients were assessed at weekly intervals for efficacy and safety evaluation. Fourteen patients successfully completed 20...
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