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The murine double minute 2 (MDM2) oncogene exerts major oncogenic activities in human cancers; it is not only the best‐documented negative regulator of the p53 tumor suppressor, but also exerts p53‐independent activities. There is an increasing interest in developing MDM2‐based targeted therapies. Several classes of MDM2 inhibitors have been evaluated in preclinical models, with a few entering clinical...
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