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The nucleus accumbens in the ventral striatum is considered a pivotal structure in food reward and addictive behavior. Injection of the mu-opioid agonist DAMGO into this structure powerfully stimulates intake of preferred palatable foods such as high fat, but the downstream neural mechanisms are not well understood. We have previously shown that accumbens-hypothalamic projections and orexin-signaling...
Our previous work suggests that the caudal brainstem mechanisms of food satiation may involve signaling through the mitogen-activated protein kinase ERK1/2 cascade in a population of nucleus of the solitary tract (NTS) neurons. Peripheral administration of CCK and fourth ventricular injection of the stable MC4-receptor agonist MTII led to rapid phosphorylation of ERK1/2 in specific neurons, and CCK...
The dorsal vagal complex in the caudal medulla is considered an important integrative area in the distributed neural network controlling food intake with melanocortin receptor-4 (MC4R) signaling playing a crucial role. Here, we used patch-clamp whole cell recording from NTS neurons to investigate the effects of MC4R ligands that have previously been shown to powerfully modulate meal structure and...
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