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Rationale Chronic ethanol (EtOH) treatment decreases the motor-impairing effects of cannabinoids and downregulates the cannabinoid type 1 (CB1) receptor. However, these studies have been limited to measures of ataxia and analysis of CB1 expression from whole-brain or hippocampal preparations. Objective To more fully assess the interactions between ethanol and cannabinoids, a tetrad of four well-characterized...
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