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Dynamic contrast enhanced MRI contrast agent kinetics in malignant tumors are typically complex, requiring multicompartment tumor models for adequate description. For consistent comparisons among tumors or among successive studies of the same tumor, we propose to estimate the total contrast agent–accessible volume fraction of tumor, including blood plasma, vpe, and an average transfer rate constant...
Here, we describe an automated nonparametric method for evaluating gadolinium‐diethylene triamine pentaacetic acid (Gd‐DTPA) kinetics, based on dynamic contrast‐enhanced–MRI scans of glioblastoma patients taken before and after treatment with bevacizumab; no specific model or equation structure is assumed or used. Tumor and venous blood concentration‐time profiles are smoothed, using a robust algorithm...
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