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Huntington's disease (HD) is one of nine known conditions caused by a CAG trinucleotide repeat expansion that is translated into a polyglutamine tract in the disease protein. Genetic and transgenic data suggest that the primary effect of these CAG/polyglutamine expansions is to confer a toxic gain-of-function on the mutant protein. The cellular pathology of all known polyglutamine diseases is characterised...
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